Extra on the pathophysiology of lymphedema and lymphedema clinics
First – The function of the lymphatic system:
The core competencies of the lymphatic system are the elimination of excessive molecular weight proteins and immunological position (infections, cancer).
In the case of lymphedema, which remain excessive molecular weight proteins in the interstitial fluid, leading to an increase in interstitial oncotic pressure, leading to swelling.
The lack of substitution (the venous system is not able to remove these proteins), which explains the persistence of edema (engagement of proteins), and after diuretic therapy (which causes degradation of the effect on proteins).
Secondly – Implications of lymphedema:
This high protein promotes fibrosis and pores and skin infections.
The presence of proteins and stimulates collagen breakdown products of fibroblasts responsible exercise of fibrosis.
In lymphedema, there is a hyperplastic fibrosis, but no ulceration, in contrast to venous insufficiency.
Streptococcal bacterial cellulitis or lymphangitis often complicated lymphedema.
Lymphedema in the pores and skin changes are primarily the skin (increased strength, water retention), but subcutaneous (fat lobules of the subcutaneous tissue are larger).
Primary lymphedema of the child are often followed by lymphatic hypoplasia of width.
The networks are replaced to delay, in some ways, medical events take place, the place in an episode of genital life (puberty, pregnancy), trauma, surgery or irradiation.
Study of superficial lymphatic network in microlymphographie show expansion of the lymphatic system (primary lymphedema occurs after puberty) or with a complete superficial lymphatic aplasia (congenital lymphedema type I) or superficial lymphatic ectasia (congenital lymphedema Sun II).
Lymphedema scientific
Lymphoedema is very early in the neonatal period or at puberty or later, after 35 years.
The diagnosis is almost always easy in other parts of the newborn and infant (Chubby look at this age).
Secondary lymphedema is more proximal lymph congestion occurring constipation.
upper extremity is the classic “big guns” in the proximal radio-surgical treatment of early breast cancer.
Lymphedema usually with the first failure of the limbs begin.
Smaller branch, the event is of crucial importance to the top of the foot edema, which is “non-pitting” in the early forms, it is not constant.
The toes are stocky, with transverse folds marked, especially at the base.
Stemmer sign is pathognomonic of lymphedema of the lower extremity considered: it is a thickening of the skin and pores times, highlighted by pinching the top of the second toe.
Then deletes lymphedema talus (filling retromalleolar areas), what “public” one aspect of the leg.
This leads to fibrosis of the skin with fibrous papules, vegetation, and deep transverse wrinkles. Other displays are possible.
Lymphedema can be suspended up to the thigh.
It could be generalized to the genitals, or face.
In lymphoedema of the core members, only one will be reached to reduce each member or two more members, and members fall on the side of the same or opposite side.
Lymphedema of the lower extremities may reveal or accompany a enteropathy in a malformation of the lymphatic vessels (chyloed? Me, Waldmann syndrome or intestinal lymphangiectasia, lymphangiomatosis …) or an abnormality of the thoracic duct.
Kaposi’s sarcoma may occur before or accompanied by lymphedema.
In case of persistent venous insufficiency, lymphatic anomalies are observed.
The first dynamic lymphatic insufficiency, perhaps most of the time change in mechanics, lymph altered by venous stasis.
This could explain some anomalies scientific submit-thrombotic syndrome and untreated.
This could also explain the pathophysiology of fibrosis and a number of scientific anomalies seen in persistent edema, regardless of their activation …). (anasarca Elephantiasis Tropical
The core competencies of the lymphatic system are the elimination of excessive molecular weight proteins and immunological position (infections, cancer).
In the case of lymphedema, which remain excessive molecular weight proteins in the interstitial fluid, leading to an increase in interstitial oncotic pressure, leading to swelling.
The lack of substitution (the venous system is not able to remove these proteins), which explains the persistence of edema (engagement of proteins), and after diuretic therapy (which causes degradation of the effect on proteins).
Secondly – Implications of lymphedema:
This high protein promotes fibrosis and pores and skin infections.
The presence of proteins and stimulates collagen breakdown products of fibroblasts responsible exercise of fibrosis.
In lymphedema, there is a hyperplastic fibrosis, but no ulceration, in contrast to venous insufficiency.
Streptococcal bacterial cellulitis or lymphangitis often complicated lymphedema.
Lymphedema in the pores and skin changes are primarily the skin (increased strength, water retention), but subcutaneous (fat lobules of the subcutaneous tissue are larger).
Primary lymphedema of the child are often followed by lymphatic hypoplasia of width.
The networks are replaced to delay, in some ways, medical events take place, the place in an episode of genital life (puberty, pregnancy), trauma, surgery or irradiation.
Study of superficial lymphatic network in microlymphographie show expansion of the lymphatic system (primary lymphedema occurs after puberty) or with a complete superficial lymphatic aplasia (congenital lymphedema type I) or superficial lymphatic ectasia (congenital lymphedema Sun II).
Lymphedema scientific
Lymphoedema is very early in the neonatal period or at puberty or later, after 35 years.
The diagnosis is almost always easy in other parts of the newborn and infant (Chubby look at this age).
Secondary lymphedema is more proximal lymph congestion occurring constipation.
upper extremity is the classic “big guns” in the proximal radio-surgical treatment of early breast cancer.
Lymphedema usually with the first failure of the limbs begin.
Smaller branch, the event is of crucial importance to the top of the foot edema, which is “non-pitting” in the early forms, it is not constant.
The toes are stocky, with transverse folds marked, especially at the base.
Stemmer sign is pathognomonic of lymphedema of the lower extremity considered: it is a thickening of the skin and pores times, highlighted by pinching the top of the second toe.
Then deletes lymphedema talus (filling retromalleolar areas), what “public” one aspect of the leg.
This leads to fibrosis of the skin with fibrous papules, vegetation, and deep transverse wrinkles. Other displays are possible.
Lymphedema can be suspended up to the thigh.
It could be generalized to the genitals, or face.
In lymphoedema of the core members, only one will be reached to reduce each member or two more members, and members fall on the side of the same or opposite side.
Lymphedema of the lower extremities may reveal or accompany a enteropathy in a malformation of the lymphatic vessels (chyloed? Me, Waldmann syndrome or intestinal lymphangiectasia, lymphangiomatosis …) or an abnormality of the thoracic duct.
Kaposi’s sarcoma may occur before or accompanied by lymphedema.
In case of persistent venous insufficiency, lymphatic anomalies are observed.
The first dynamic lymphatic insufficiency, perhaps most of the time change in mechanics, lymph altered by venous stasis.
This could explain some anomalies scientific submit-thrombotic syndrome and untreated.
This could also explain the pathophysiology of fibrosis and a number of scientific anomalies seen in persistent edema, regardless of their activation …). (anasarca Elephantiasis Tropical
http://www.paparizouonline.com/extra-on-the-pathophysiology-of-lymphedema-and-lymphedema-clinics.html
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